Alternative cell death mechanisms in development and beyond
نویسندگان
چکیده
منابع مشابه
Alternative cell death mechanisms in development and beyond.
A canonical regulatory pathway involving the members of the Bcl-2 and caspase families has been established to regulate developmental apoptosis in nematodes and flies. However, mutant mice that have major deficiencies in this apoptosis pathway show only relatively minor developmental defects. Recent revelations indicate that multiple mechanisms are involved in regulating cell death during mamma...
متن کاملtLivin Displays Flexibility by Promoting Alternative Cell Death Mechanisms
Livin is a member of the Inhibitor of Apoptosis (IAP) protein family that inhibits apoptosis triggered by a variety of stimuli. We previously demonstrated that while Livin inhibits caspase activity, caspases can cleave Livin to produce a truncated protein, tLivin and that this newly formed tLivin paradoxically induces cell death. However to date, the mechanism of tLivin-induced cell death is no...
متن کاملCell death in early neural development: beyond the neurotrophic theory.
The important effect of cell death on projecting neurons during development is well established. However, this mainstream research might have diverted recognition of the cell death that occurs at earlier stages of neural development, affecting proliferating neural precursor cells and young neuroblasts. In this article, we briefly present observations supporting the occurrence of programmed cell...
متن کاملAlternative Cell Death Pathways and Cell Metabolism
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revi...
متن کاملCell Death in Development
that the morphology of liver cells exposed to toxins, and Boston, Massachusetts 02115 lymphocytes treated with hormones, was the same as that described by the embryologist Glucksmann earlier Physiological mechanisms of cell death are used by in the century, they coined a new term, " apoptosis, " for multicellular organisms for development and morpho-cell deaths with this distinct morphology—whe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2010
ISSN: 0890-9369
DOI: 10.1101/gad.1984410